沈敬山，男，1981年毕业于长春冶金地质学校，1981-1992年在山东省地勘局工作。1995 年获中国药科大学药物化学专业硕士学位，1998年获中国科学院上海药物研究所药物化学专业博士学位。
主要成就
科研成就
研究方向
药物发现与成药性评估（中枢神经系统与心血管系统药物研究）;绿色可持续性有机合成路线设计、工艺研究和产业化。
科研成果
已有三个化学仿制药品种的新药证书。共有六个化学仿制药和四个中药仿制药研制成功并上市。目前，具有自主知识产权的候选新药TPN729（用于ED）已于2011年12月份作为1.1类化学药品上报国家食品药品监督管理总局申请临床研究。TPN171（用于ED与PAH）、TPN507（用于精神分裂症）、TPN102（用于癫痫）在临床前研究阶段。已申请药物研究方面的专利二十多项，获授权专利六项。
设计出了多条具有自主知识产权、更适于生产实际应用的新路线，使成本消耗更低，化学过程更简易、可控、安全，并且最大程度地减少对人员健康和环境资源的不利影响。目前已申请了三十多项工艺专利，获授权专利九项，有多个项目（如替米沙坦、顺阿曲库等）的节能降耗与清洁操作实用化方案应用于工业生产中。
科研项目
成功主持或参与了“新药创制”国家重大专项、国家863计划、科技支撑计划、国家自然科学基金等多项国家级及上海市的重大专项或基金项目
代表
Guan Wang, Zheng Liu, Tiantian Chen, Zhen Wang, Huaiyu Yang, Mingyue Zheng, Jing Ren, Guanghui Tian, Xiaojun Yang, Li Li, Jianfeng Li, Jin Suo, Rongxia Zhang, Xiangrui Jiang, Nicholas Kenneth Terrett, Jingshan Shen*, Yechun Xu*, Hualiang Jiang*. Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5. J. Med. Chem
Yongjun Mao, Zheng Liu, Xiaojun Yang, Xiangfei Xia, Rongxia Zhang, Jianfeng Li, Xiangrui Jiang, Kai Xie, Jin Zheng, Hui Zhang, Jin Suo, Jingshan Shen*. A New and Improved Process for N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)乙酰胺 Org. Process Res. Dev
Qiang Zhang, Jian-Feng Li, Guang-Hui Tian, Rong-Xia Zhang, Jin Sun, Jin Suo, Xin Feng, Du Fang, Xiang-Rui Jiang*, Jing-Shan Shen. A Practical and Enantioselective Synthesis of Tapentadol. Tetrahedron: Asymmetry
Zhijian Xu, Zheng Liu, Tong Chen, TianTian Chen, Zhen Wang, Guanghui Tian, Jing Shi, Xuelan Wang, Yunxiang Lu, Xiuhua Yan, Guan Wang, Hualiang Jiang, Kaixian Chen, Shudong Wang, Yechun Xu, Jingshan Shen*, and Weiliang Zhu*. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. Journal of Medicinal 化学
Zhi Chen, Guanghui Tian, Zhen Wang, Hualiang Jiang, Jingshan Shen*, Weiliang Zhu*. Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity. J. Chem. Inf. Model
Yongjun Mao, Guanghui Tian, Zheng Liu, Jingkang Shen, Jingshan Shen*. An Improved Synthetic Route for Preparative Process of 盐酸伐地那非 Org. Process Res. dev
Xiangrui Jiang, Jianfeng Li, Rongxia Zhang, Hongli Guo, Shaolei Huang, Jingshan Shen*. Improved Preparation of 3-(1,1-Dimethylallyl)decursinol. J. Heterocycl. Chem
Hongliang Duan, Jin Zheng, Qinglin Lai, Zheng Liu, Guanghui Tian, Zhen Wang, Jianfeng Li, Jingshan Shen*. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6. Bioorg. Med. Chem. Lett
Xiangrui Jiang; Jianfeng Li; Rongxia Zhang; Yi Zhu; Jingshan Shen*. An Improved Preparation Process for 吉西他滨 Org. Process Res. Dev
Qingjie Zhao, Yuanyuan Lou, Ruisheng Xiong, Haihong Li, Jingshan Shen*. Regioselective Synthesis of 4azido-Neu2en5,7Ac21Me and its intramolecular Transformation to 4azido-Neu2en5,9Ac21Me. Carbohydr. Res.
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